Director, Non-clinical Pharmacology T&I

CSL | Melbourne | AU

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CSL's R&D organisation is accelerating innovation to deliver greater impact for patients. With a project-led structure and a focus on collaboration, we’re building a future-ready team that thrives in dynamic biotech ecosystems. Joining CSL now means being part of an agile team committed to developing therapies that make a meaningful difference worldwide.


We are seeking a Therapeutic Area (TA) Pharmacology Lead (Transplant & Immunology) to drive the design, execution, and interpretation of in vivo pharmacology studies that support drug discovery and development. This role is pivotal in characterising the pharmacological profile of novel therapeutic candidates through internal studies and external collaborations.

Your Key Responsibilities

Scientific Leadership

  • Define and lead the nonclinical pharmacology strategy for discovery and development programs within the therapeutic area (T&I)
  • Design and oversee in vivo efficacy, pharmacodynamic (PD), and mechanism-of-action studies in relevant animal models.
  • Guide the selection and validation of disease models that best represent human pathophysiology.

Study Design & Execution

  • Develop and implement study protocols for pharmacology, target engagement, and biomarker evaluation.
  • Identify and manage external collaborators or CROs; ensure high-quality, timely execution of studies.
  • Analyse and interpret complex data sets to inform compound progression and candidate selection.

Cross-Functional Collaboration

  • Serve as Senior Pharmacology Lead on TA teams.
  • Partner with PK, Toxicology, and Translational Science to integrate pharmacology data into development plans.
  • Provide expert input on pharmacology-related issues for project teams and due diligence activities.

Documentation & Communication

  • Prepare study reports, presentations, and regulatory documents (IND, CTA).
  • Present findings to internal stakeholders and external collaborators.

Team Leadership

  • Lead and mentor a team of Principal and Senior Scientists, including hands-on in vivo work.
  • Foster a culture of scientific excellence, innovation, and continuous learning.

Your Qualifications & Experience

  • Ph.D. in Pharmacology, Physiology, Biomedical Sciences, or related field.
  • 10+ years of experience in pharmacology within pharma/biotech or academia with deep understanding of pharmaceutical development.
  • Strong expertise in in vivo pharmacology, disease models, and translational science for disease areas relevant to Transplant and/or Immunology.
  • Familiarity with regulatory expectations for nonclinical pharmacology data.
  • Proven ability to manage multiple projects and timelines.
  • Strategic thinker with excellent problem-solving, communication, and interpersonal skills.
  • Experience across multiple therapeutic areas and modalities is highly desirable
  • Extensive knowledge and subject matter expertise in disease biology related to Transplant and/or Immunology-related conditions is essential.

Ready to make an impact? Apply now and help shape the future of therapeutic innovation.

Our Benefits

We encourage you to make your well-being a priority. It’s important and so are you. Learn more about how we care at CSL.

About CSL

CSL is a leading global biotechnology company with a dynamic portfolio of life-saving medicines, including those that treat haemophilia and immune deficiencies, as well as vaccines to prevent influenza. Since our start in 1916, we have been driven by our promise to save lives through innovation. Learn more about CSL.

We want CSL to reflect the world around us

At CSL, Inclusion and Belonging is at the core of our mission and who we are. It fuels our innovation day in and day out. By celebrating our differences and creating a culture of curiosity and empathy, we are able to better understand and connect with our patients and donors, foster strong relationships with our stakeholders, and sustain a diverse workforce that will move our company and industry into the future. Learn more Inclusion and Belonging | CSL

Do work that matters at CSL!


Information :

  • Company : CSL
  • Position : Director, Non-clinical Pharmacology T&I
  • Location : Melbourne
  • Country : AU

How to Submit an Application:

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Post Date : 2025-11-01 | Expired Date : 2025-12-01